Abstract. Background: Diabetic peripheral neuropathy (DPN) is common in diabetic nephropathy (DN); There is no information if secondary hyperparathyroidism (SHP) increases its symptoms. The purpose was to determine DPN by signs in patients with SHP. Methods: It is a case-control study. Control patients (CG) with DN and parathyroid hormone (PTH) values<60pg/ml. The Hyperparathyroidism group (HG), patients with DN and PTH≥60pg/ml and HPS biochemical criteria. The variables were, among others, the presence of DPN signs; they were compared with Student's t and Chi2. Results: There were 60 participants in each group, 35(58.3%) men in CG vs.33(55.0%) in GH(p=0.713). The age of the CG was 67±11.0years, vs 72±11years HG (p=0.009); The glomerular filtration rate (GFR) in the CG was 53.82±25.13 vs in HG 35.34±18.43ml/min/1.73m2(p<0.001). The PTH in the CG was 38.02±15.32pg/ml, in GH 119.07±84.33pg/ml(p<0.001). The NPD due to symptoms in CG was 28.3% and in GH 36.6%(p=0.330). Neuropathy due to signs in the CG was 38.3% and in GH 83.3%(p<0.001). The HG Odds Ratio to present neuropathy due to signs was 8.044(95%CI3.42–18.92). Conclusion: There was a statistical association between HPS and signs of NPD in patients with DN in our center.

Resumo. Fundo: A neuropatia diabética periférica (NDP) é comum na nefropatia diabética (ND); não há informações se o hiperparatireoidismo secundário (HPS) aumenta seus sintomas. O objetivo foi determinar NDP por sinais em pacientes com HPS. Material e Métodos: É um estudo de controlo de casos. O grupo controlo de doentes (GC) com ND e valores de paratormônio (PTH) <60pg / ml. Grupo de hiperparatireoidismo (GH), pacientes com ND e PTH≥60pg / ml e critérios bioquímicos de HPS. As variáveis foram; entre outras, a presença de sinais de NDP, foram comparados com o teste T de "Student" e o qui-quadrado. Resultados: Houve 60 participantes em cada grupo, 35 (58,3%) homens no GC vs. 33 (55,0%) em GH (p = 0,713). A idade do GC foi de 67 ± 11,0 anos, vs 72 ± 11 anos GH (p = 0,009); A taxa de filtração glomerular (TFG) no GC foi 53,82 ± 25,13 vs GH 35,34 ± 18,43ml/min/1,73m2 (p <0,001). O PTH no GC foi de 38,02 ± 15,32 pg/ml, em GH 119,07 ± 84,33 pg/ml (p <0,001). A NDP devido aos sintomas no GC foi de 28,3% e 36,6% no GH (p = 0,330). A neuropatia por sinais no GC foi de 38,3% e no GH 83,3% (p <0,001). O Odds Ratio de GH para neuropatia presente devido a sinais foi de 8,044 (IC 95% 3,42–18,92). Conclusão: Houve maiores sinais de NPD em pacientes com HPS em nosso centro.